A team of researchers from the University of California, Irvine has discovered a signaling molecule that stimulates hair growth in the human body. A molecule called SCUBE3 acts as an active agent that contributes to hair growth. In a recent study, researchers examined dermal papilla cells, the signal-producing fibroblasts at the bottom of each hair follicle, and the genetic structure that gives them the ability to control hair growth. These dermal papilla cells can either make the follicles dormant or trigger them to increase hair growth.
SCUBE3 are active molecules that help generate this functionality of dermal papilla cells. Corresponding author of the study, Maxim Plikus, said Statement“We revealed that the SCUBE3 signaling molecule, which dermal papilla cells produce naturally, is the messenger used to ‘tell’ neighboring hair stem cells to divide, which initiates new hair growth. initiates.”
Researchers made this discovery with the help of a mouse model. They injected SCUBE3 subcutaneously into the skin of a mouse into which human scalp follicles had been implanted. This activity resulted in new growth in dormant human follicles as well as in surrounding mouse follicles. “Studying this mouse model allowed us to identify SCUBE3 as a previously unknown signaling molecule that may drive excessive hair growth,” said study co-first author Yingzhi Liu.
research was published in developmental cell,
Researchers believe the study may contribute to designing therapeutic treatments for androgenetic alopecia, a common condition of hair loss that is prevalent in both men and women. “These experiments provide proof-of-principle data that SCUBE3 or derived molecules may be a promising therapeutic for hair loss,” said co-first author, Christian Guerrero-Juarez.
Research validates the preclinical potential of SCUBE3 and may prompt the production of new, effective and naturally occurring compounds that aid hair loss in men and women. Currently, there is less availability of oral medications that help the consumer to prevent hair loss.
Only two drugs — finasteride and minoxidil — are approved by the Food and Drug Administration to be used to treat androgenetic alopecia. Furthermore, these drugs are not universally effective and have to be consumed daily to maintain their effectiveness.
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